7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene

Base Information

Chemical Name:7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene
CAS No.:858946-67-5
Molecular Formula:C₃₀H₃₉Br₂FO₂Si₂
Molecular Weight:666.616
Hs Code.:

7-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene

Synonyms:7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene

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Chemical Property of 7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene

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Technology Process of 7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene

There total 9 articles about 7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6836-19-7
7-Methoxy-1-tetralone

: 858946-67-5
7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene

Guidance literature:: Multi-step reaction with 9 steps

1.1: ZnI₂ / benzene / 20 °C

1.2: POCl₃; pyridine / benzene / 6 h / Heating

2.1: p-cymene / Pd/C / Heating

3.1: 0.88 g / C₆H₅N*HCl / 2 h / 190 °C

4.1: Br₂; acetic acid / 6 h / 100 °C

4.2: aq. HCl; SnCl₂ / 1 h / 100 °C

5.1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

6.1: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

7.1: 7.68 g / imidazole / dimethylformamide

8.1: DIBAL / toluene / -78 - 20 °C

9.1: zinc; PPh₃ / CH₂Cl₂ / 3 h / 20 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylisopropylbenzene; C₆H₅N*HCl; bromine; diisobutylaluminium hydride; sodium carbonate; acetic acid; triphenylphosphine; zinc(II) iodide; zinc; palladium on activated charcoal; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; benzene; 5.1: Suzuki coupling;
DOI:10.1021/jm058173s

Reference yield:

: 158365-53-8
7-methoxy-3,4-dihydronaphthalene-1-carbonitrile

: 858946-67-5
7-(tert-butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-phenyl]-1-(2,2-dibromo-vinyl)-naphthalene

Guidance literature:: Multi-step reaction with 8 steps

1.1: p-cymene / Pd/C / Heating

2.1: 0.88 g / C₆H₅N*HCl / 2 h / 190 °C

3.1: Br₂; acetic acid / 6 h / 100 °C

3.2: aq. HCl; SnCl₂ / 1 h / 100 °C

4.1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

5.1: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

6.1: 7.68 g / imidazole / dimethylformamide

7.1: DIBAL / toluene / -78 - 20 °C

8.1: zinc; PPh₃ / CH₂Cl₂ / 3 h / 20 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylisopropylbenzene; C₆H₅N*HCl; bromine; diisobutylaluminium hydride; sodium carbonate; acetic acid; triphenylphosphine; zinc; palladium on activated charcoal; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; 4.1: Suzuki coupling;
DOI:10.1021/jm058173s