trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide

Base Information

• Chemical Name: trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide
• CAS No.: 749866-15-7
• Molecular Formula: C₁₃H₂₄N₂O₃
• Molecular Weight: 256.345
• Mol file: 749866-15-7.mol

Synonyms:trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide

Chemical Property of trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide

There total 4 articles about trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5) → trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide (749866-15-7)

Guidance literature:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1h;

With ammonia; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1002/ardp.200300813

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide (749866-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water / 18 h / 20 °C / Industrial scale

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 3 h / -10 - 20 °C

2.2: 18 h / -10 - 20 °C

With chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; water;

Reference yield:

trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → trans-4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid amide (749866-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water / 18 h / 20 °C / Industrial scale

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 3 h / -10 - 20 °C

2.2: 18 h / -10 - 20 °C

With chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; water;

upstream raw materials:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

di-tert-butyl dicarbonate

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Downstream raw materials:

trans-(4-cyanocyclohexylmethyl)carbamic acid tert-butyl ester

trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester

C₃₁H₅₃ClN₆O₄

(x)BrH*C₂₇H₅₁N₈O₃P