2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Base Information

Chemical Name:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone
CAS No.:1380427-01-9
Molecular Formula:C₂₆H₂₂ClF₃N₄O₄
Molecular Weight:546.933
Hs Code.:

Synonyms:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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Chemical Property of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

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Technology Process of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

There total 9 articles about 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380427-00-8
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

: 74-88-4
methyl iodide

: 1380427-01-9
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 14001-66-2
5-bromo-2-methoxypyrimidine

: 1380427-01-9
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3 h / 130 °C / Inert atmosphere

2: hydrogen / palladium on activated charcoal / methanol / 48 h / 50 °C

3: sodium hydride / 1,2-dimethoxyethane / 0 - 25 °C / Inert atmosphere

4: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 160 °C / Microwave irradiation

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; palladium diacetate; tris-(o-tolyl)phosphine; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 1: Heck Reaction;

Reference yield:

: 107166-90-5
(E)-methyl 3-(2-methoxy-5-pyrimidinyl)acrylate

: 1380427-01-9
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / methanol / 48 h / 50 °C

2: sodium hydride / 1,2-dimethoxyethane / 0 - 25 °C / Inert atmosphere

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 160 °C / Microwave irradiation

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane;