5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

Base Information

Chemical Name:5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine
CAS No.:1370548-56-3
Molecular Formula:C₃₉H₄₄N₂O₁₁
Molecular Weight:716.785
Hs Code.:

Synonyms:5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

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Chemical Property of 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

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Technology Process of 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

There total 3 articles about 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1370548-54-1
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

: 96-34-4
methyl chloroacetate

: 1370548-56-3
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; regioselective reaction;
DOI:10.1002/cbdv.201100103

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1370548-56-3
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap; triethylamine / 1 h / 20 °C

2: ammonium hydroxide / methanol / 2.5 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C

With pyridine; dmap; ammonium hydroxide; sodium hydride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201100103

Reference yield:

: 40615-37-0
3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine

: 1370548-56-3
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap; triethylamine / 1 h / 20 °C

2: ammonium hydroxide / methanol / 2.5 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C

With pyridine; dmap; ammonium hydroxide; sodium hydride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201100103