sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

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Chemical Name:sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine
CAS No.:1370548-57-4
Molecular Formula:C₃₈H₄₁N₂O₁₁*Na
Molecular Weight:724.74
Hs Code.:

Synonyms:sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

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Chemical Property of sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

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Technology Process of sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

There total 5 articles about sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1370548-56-3
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[ (tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydro-3'-O-(2-methoxy-2-oxoethyl)thymidine

: 1370548-57-4
sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1002/cbdv.201100103

Reference yield:

: 40615-37-0
3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine

: 1370548-57-4
sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; dmap; triethylamine / 1 h / 20 °C

2: ammonium hydroxide / methanol / 2.5 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C

4: sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; dmap; ammonium hydroxide; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201100103

Reference yield:

: 1370548-51-8
3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

: 1370548-57-4
sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / methanol / 2.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C

3: sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

With ammonium hydroxide; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201100103