N₁-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N₄-(tetrahydro-2H-pyran-2-yloxy)terephthalamide

Base Information

• Chemical Name: N₁-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N₄-(tetrahydro-2H-pyran-2-yloxy)terephthalamide
• CAS No.: 1143460-21-2
• Molecular Formula: C₂₇H₂₅N₅O₄S
• Molecular Weight: 515.593

Synonyms:N₁-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N₄-(tetrahydro-2H-pyran-2-yloxy)terephthalamide

Chemical Property of N₁-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N₄-(tetrahydro-2H-pyran-2-yloxy)terephthalamide

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Technology Process of N₁-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N₄-(tetrahydro-2H-pyran-2-yloxy)terephthalamide

There total 1 articles about N₁-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N₄-(tetrahydro-2H-pyran-2-yloxy)terephthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

O-2-tetrahydro-2H-pyranhydroxylamine (6723-30-4) + 4-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenylcarbamoyl)benzoic acid (1143460-16-5) → N1-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N4-(tetrahydro-2H-pyran-2-yloxy)terephthalamide (1143460-21-2)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm800988r

Reference yield: 70.0%

N1-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-N4-(tetrahydro-2H-pyran-2-yloxy)terephthalamide (1143460-21-2) → N1-hydroxy-N4-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)terephthalamide hydrochloride (1143460-24-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 16h;

DOI:10.1021/jm800988r

upstream raw materials:

O-2-tetrahydro-2H-pyranhydroxylamine

4-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenylcarbamoyl)benzoic acid

Downstream raw materials:

N₁-hydroxy-N₄-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)terephthalamide hydrochloride

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