1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester
CAS No.:207554-17-4
Molecular Formula:C₂₀H₂₇NO₅
Molecular Weight:361.438
Hs Code.:

Synonyms:1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

Suppliers and Price of 1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

There total 2 articles about 1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 106-93-4
ethylene dibromide

: 207554-16-3
4-(Benzyl-tert-butoxycarbonyl-amino)-3-oxo-butyric acid ethyl ester

: 207554-17-4
1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetone; for 6h; Heating;
DOI:10.1248/cpb.46.587

Reference yield:

: 76315-01-0
N-benzyl-N-(tert-butoxycarbonyl)glycine

: 207554-17-4
1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N,N'-carbonyldiimidazole, 2.) MgCl₂ / 1.) THF, RT, 2 h, 2.) THF, a) 50 deg C, 6 h, b) RT, 16 h

2: 72 percent / K₂CO₃ / acetone / 6 h / Heating

With potassium carbonate; 1,1'-carbonyldiimidazole; magnesium chloride; In acetone;
DOI:10.1248/cpb.46.587

Reference yield:

: 207554-17-4
1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester

: 127199-45-5
(7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

2: toluene / 0.5 h / Heating

3: 65 percent / 0.1percent aq. K₂HPO₄/KH₂PO₄ buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880

4: 1.) Ph₃P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH₄ / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h

5: 92 percent / toluene / 18 h / Ambient temperature

6: 90 percent / H₂ / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr

With dipotassium hydrogenphosphate; lithium aluminium tetrahydride; KH₂PO₄ buffer pH=6.0; diphenylphosphoranyl azide; hydrogen; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; dichloromethane; toluene;
DOI:10.1248/cpb.46.587