N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

Base Information

Chemical Name:N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide
CAS No.:54042-46-5
Molecular Formula:C₂₇H₂₂ClN₅O₃
Molecular Weight:499.956
Hs Code.:

<i>N</i>-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4<i>H</i>-[1,2,4]triazol-3-ylmethyl]-phthalimide

Synonyms:N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

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Technology Process of N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

There total 5 articles about N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

: 51-80-9
bis-(dimethylamino)methane

: 54485-85-7
N-[4-(2-benzoyl-4-chloro-phenyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

: 54042-46-5
N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

Guidance literature:: With acetyl chloride; In N,N-dimethyl-formamide; at 50 - 54 ℃; for 25h;
DOI:10.1002/jhet.5570170331

Reference yield:

: 59010-35-4
1,3-Dioxo-2-isoindolineacetic Acid, <methylene>hydrazine

: 54042-46-5
N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / trifluoroacetic acid / toluene / 1.5 h / 100 - 110 °C

2: 84.9 percent / acetyl chloride / dimethylformamide / 25 h / 50 - 54 °C

With acetyl chloride; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570170331

Reference yield:

: 6780-38-7
N-phthaloylglycine chloride

: 54042-46-5
N-[4-(2-benzoyl-4-chloro-phenyl)-5-(dimethylamino-methyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide

Guidance literature:: Multi-step reaction with 3 steps

1: 90.7 percent / pyridine / tetrahydrofuran / 6 h / 0 - 25 °C

2: 53 percent / trifluoroacetic acid / toluene / 1.5 h / 100 - 110 °C

3: 84.9 percent / acetyl chloride / dimethylformamide / 25 h / 50 - 54 °C

With pyridine; acetyl chloride; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570170331