(E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester
CAS No.:819868-10-5
Molecular Formula:C₁₈H₂₃NO₄S
Molecular Weight:349.451
Hs Code.:

Synonyms:(E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

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Chemical Property of (E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

Chemical Property:

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Technology Process of (E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

There total 1 articles about (E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132341-85-6
(+)-(2E)-(4S)-ethyl 4-hydroxy-2-pentenoate

: 161040-05-7
N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide

: 819868-10-5
(E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ja046824o

Reference yield:

: 819868-10-5
(E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

: 819868-11-6
N-but-3-ynyl-N-(4-hydroxy-1-methyl-but-2-enyl)-4-methyl-benzenesulfonamide

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at -78 ℃;
DOI:10.1021/ja046824o

Reference yield:

: 819868-10-5
(E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

: 819868-12-7
1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

Guidance literature:: Multi-step reaction with 2 steps

1: 0.74 g / DIBAL-H / diethyl ether / -78 °C

2: 0.898 g / 4-DMAP / CH₂Cl₂ / 20 °C

With dmap; diisobutylaluminium hydride; In diethyl ether; dichloromethane;
DOI:10.1021/ja046824o