1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

Base Information

Chemical Name:1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne
CAS No.:819868-12-7
Molecular Formula:C₂₂H₃₅NO₃SSi
Molecular Weight:421.676
Hs Code.:

Synonyms:1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

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Chemical Property of 1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

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Technology Process of 1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

There total 3 articles about 1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 819868-11-6
N-but-3-ynyl-N-(4-hydroxy-1-methyl-but-2-enyl)-4-methyl-benzenesulfonamide

: 819868-12-7
1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;
DOI:10.1021/ja046824o

Reference yield:

: 161040-05-7
N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide

: 819868-12-7
1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropyl azodicarboxylate; Ph₃P / tetrahydrofuran / 2 h / 20 °C

2: 0.74 g / DIBAL-H / diethyl ether / -78 °C

3: 0.898 g / 4-DMAP / CH₂Cl₂ / 20 °C

With dmap; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/ja046824o

Reference yield:

: 819868-10-5
(E)-(R)-4-[But-3-ynyl-(toluene-4-sulfonyl)-amino]-pent-2-enoic acid ethyl ester

: 819868-12-7
1-[[(4R)-(E)-4-(tert-butyldimethylsilyloxy)-4-methylbut-2-enyl]-(4-methylbenzenesulfonyl)amino]but-3-yne

Guidance literature:: Multi-step reaction with 2 steps

1: 0.74 g / DIBAL-H / diethyl ether / -78 °C

2: 0.898 g / 4-DMAP / CH₂Cl₂ / 20 °C

With dmap; diisobutylaluminium hydride; In diethyl ether; dichloromethane;
DOI:10.1021/ja046824o