tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Base Information

Chemical Name:tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate
CAS No.:1363479-89-3
Molecular Formula:C₂₆H₂₇N₃O₈S
Molecular Weight:541.582
Hs Code.:

Synonyms:tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Suppliers and Price of tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

There total 18 articles about tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1363479-87-1
tert-butyl 7-carbamoyl-1-(hydroxymethyl)-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

: 1939-99-7
benzenesulfonyl chloride

: 1363479-89-3
tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;
DOI:10.1021/jm201717y

Reference yield:

: C₁₄H₁₁IN₂

: 1363479-89-3
tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 2 h / 0 °C

2: acetic acid / 48 h / Reflux

3: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

4: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

5: 1,4-dioxane / 24 h / Inert atmosphere; Reflux

6: triethylamine / dichloromethane / 0.33 h / 0 °C

With pyridine; sulfuric acid; dihydrogen peroxide; potassium carbonate; potassium nitrate; triethylamine; In 1,4-dioxane; dichloromethane; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm201717y

Reference yield:

: 1363479-64-4
tert-butyl 7-cyano-1-(hydroxymethyl)-1H-benzo[e]indole-3(2H)-carboxylate

: 1363479-89-3
tert-butyl 1-(((benzylsulfonyl)oxy)methyl)-7-carbamoyl-5-nitro-1H-benzo[e]indole-3(2H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: dmap; triethylamine / tetrahydrofuran / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3: pyridine / 4 h / 0 °C

4: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

5: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

6: 1,4-dioxane / 24 h / Inert atmosphere; Reflux

7: triethylamine / dichloromethane / 0.33 h / 0 °C

With pyridine; dmap; sulfuric acid; dihydrogen peroxide; potassium carbonate; potassium nitrate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm201717y