6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide

Base Information

Chemical Name:6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide
CAS No.:1431649-87-4
Molecular Formula:C₁₈H₁₁F₃N₆O₂
Molecular Weight:400.32
Hs Code.:

Synonyms:6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide

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Chemical Property of 6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide

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Technology Process of 6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide

There total 5 articles about 6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1431654-39-5
6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-amine

: 6299-87-2
6-hydroxypyrimidine-4-carboxylic acid

: 1431649-87-4
6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide

Guidance literature:: With pyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; for 72h; Reflux;

Reference yield:

: 1150566-27-0
6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

: 1431649-87-4
6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 130 °C / Microwave irradiation

2.1: water; sodium hydroxide / 0.33 h / 70 °C

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 25 °C / Reflux

3.2: 16 h

4.1: hydrogen; palladium on activated carbon / methanol; tetrahydrofuran / 16 h / 25 °C

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / acetonitrile / 72 h / Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; palladium on activated carbon; water; hydrogen; caesium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; acetonitrile;

Reference yield:

: 1431654-38-4
benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

: 1431649-87-4
6-hydroxy-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium on activated carbon / methanol; tetrahydrofuran / 16 h / 25 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / acetonitrile / 72 h / Reflux

With pyridine; palladium on activated carbon; hydrogen; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; acetonitrile;