benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

Base Information

Chemical Name:benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate
CAS No.:1431654-38-4
Molecular Formula:C₂₁H₁₅F₃N₄O₂
Molecular Weight:412.371
Hs Code.:

Synonyms:benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

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Chemical Property of benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

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Technology Process of benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

There total 3 articles about benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1431653-85-8
6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1431654-38-4
benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

Guidance literature:: 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 25 ℃; for 3h; Reflux;

benzyl alcohol; In toluene; for 16h;

Reference yield:

: 1150566-27-0
6-chloroimidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester

: 1431654-38-4
benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 130 °C / Microwave irradiation

2.1: water; sodium hydroxide / 0.33 h / 70 °C

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 25 °C / Reflux

3.2: 16 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; water; caesium carbonate; triethylamine; sodium hydroxide; In 1,4-dioxane; toluene;

Reference yield:

: 1431653-84-7
ethyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxylate

: 1431654-38-4
benzyl 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / 0.33 h / 70 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 25 °C / Reflux

2.2: 16 h

With diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In toluene;