N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide

Base Information

Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide
CAS No.:1005780-56-2
Molecular Formula:C₂₁H₁₈N₆O₄
Molecular Weight:418.412
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide

There total 5 articles about N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 49783-72-4
3-methylisoxazole-5-carbonyl chloride

: 1005777-50-3
N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-yl]cyclopropanecarboxamide

: 1005780-56-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide

Guidance literature:: In N,N-dimethyl acetamide; at 20 ℃;
DOI:10.1016/j.bmc.2013.01.074

Reference yield: 22.0%

: 4857-42-5
3-methyl-5-isoxazolecarboxylic acid

: 79-37-8
oxalyl dichloride

: 1005777-50-3
N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-yl]cyclopropanecarboxamide

: 1005780-56-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1005785-69-2
ethyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate

: 1005780-56-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methylisoxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: barium hydroxide octahydrate; water / 1-methyl-pyrrolidin-2-one / 8 h / 120 °C

2: N,N-dimethyl acetamide / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 30?min / 180 °C / Microwave irradiation

4: N,N-dimethyl acetamide / 20 °C

With barium hydroxide octahydrate; water; potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.074