4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

Base Information

Chemical Name:4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid
CAS No.:913078-82-7
Molecular Formula:C₂₅H₂₄F₃NO₈S
Molecular Weight:555.529
Hs Code.:

Synonyms:4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

Suppliers and Price of 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

There total 12 articles about 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 913078-81-6
dimethyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalate

: 913078-82-7
4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol; water;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 209688-18-6
2-nitro-5-trifluoromethylphenyl methoxymethyl ether

: 913078-82-7
4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 80 percent / potassium carbonate / dimethylformamide / 1.5 h / 70 °C

6: 99 percent / sodium hydroxide / dioxane; methanol; H₂O

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 402-17-5
2-nitro-5-trifluoromethylphenol

: 913078-82-7
4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phthalic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 80 percent / potassium carbonate / dimethylformamide / 1.5 h / 70 °C

6: 99 percent / sodium hydroxide / dioxane; methanol; H₂O

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067