4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

Base Information

Chemical Name:4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide
CAS No.:1187448-70-9
Molecular Formula:C₁₉H₂₀ClN₃O₄S₂
Molecular Weight:453.97
Hs Code.:

Synonyms:4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

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Chemical Property of 4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

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Technology Process of 4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

There total 12 articles about 4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943434-47-7
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

: 1187449-24-6
4-bromo-5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine

: 1187448-70-9
4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 170 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 1187448-70-9
4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 56 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 °C / Inert atmosphere; Reflux

3.1: sodium hydroxide / 1,4-dioxane; water / 20 - 30 °C / Inert atmosphere

4.1: Oxone_.(R). / methanol; water / 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane; water / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 170 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; hydroxylamine hydrochloride; potassium acetate; sodium acetate; potassium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 6309-59-7
tetrahydro-4H-thiopyran-4-one oxime

: 1187448-70-9
4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 25 °C / Inert atmosphere; Reflux

2.1: sodium hydroxide / 1,4-dioxane; water / 20 - 30 °C / Inert atmosphere

3.1: Oxone_.(R). / methanol; water / 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane; water / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 170 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; potassium acetate; potassium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;