1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

Base Information

Chemical Name:1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol
CAS No.:444806-78-4
Molecular Formula:C₂₄H₃₇NO₄Si
Molecular Weight:431.648
Hs Code.:

1-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

Synonyms:1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

There total 9 articles about 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 459867-19-7
N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-2-(3,4-dimethoxy-phenyl)-acetamide

: 444806-78-4
1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 40 ℃; for 16h;
DOI:10.1021/ol020077n

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 444806-78-4
1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-bis((2R-(biphenyl(HO)C)pyrrolidino)Me)-4-MePhOH; Et₂Zn / tetrahydrofuran / 24 h / -35 °C

2: 90 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C

3: triethylamine / tetrahydrofuran / -78 - 0 °C

4: 85 percent / LiAlH₄ / diethyl ether / 16 h / 40 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; 2,6-bis((2R-(biphenyl(HO)C)pyrrolidino)Me)-4-MePhOH; diethylzinc; In tetrahydrofuran; diethyl ether; ethanol; 1: Henry reaction;
DOI:10.1021/ol020077n

Reference yield:

: 459867-22-2
1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-nitro-ethanol

: 444806-78-4
1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C

2: triethylamine / tetrahydrofuran / -78 - 0 °C

3: 85 percent / LiAlH₄ / diethyl ether / 16 h / 40 °C

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/ol020077n