459867-22-2

Basic information

• Product Name: 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-nitro-ethanol
• Synonyms: 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-nitro-ethanol
• CAS NO: 459867-22-2
• Molecular Weight: 297.426
• Mol File: 459867-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-nitro-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-nitro-ethanol(459867-22-2)
• EPA Substance Registry System: 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-nitro-ethanol(459867-22-2)

Safety Data

• Hazardous Substances Data: 459867-22-2(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 

Downstream Products

• 459867-19-7 N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-2-(3,4-dimethoxy-phenyl)-acetamide 
• 444806-78-4 1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-ethanol 
• 71771-90-9 denopamine 
• 444806-77-3 2-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethanol 

Relevant articles and documents

Effect of ligand structure on the zinc-catalyzed Henry reaction. Asymmetric syntheses of (-)-denopamine and (-)-arbutamine

(Matrix presented) Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the β-preceptor agonists (-)-denopamine and (-)-arbutamine.