(3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Base Information

Chemical Name:(3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol
CAS No.:168610-72-8
Molecular Formula:C₂₄H₂₆O₇
Molecular Weight:426.466
Hs Code.:

Synonyms:(3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol

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Chemical Property of (3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol

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Technology Process of (3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol

There total 13 articles about (3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 195436-19-2
[(3aS,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-yloxy]-tert-butyl-dimethyl-silane

: 168610-72-8
(3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)74390-5

Reference yield:

: 2878-55-9
3,4-(methylenedioxy)benzyl α-ethoxyethyl ether

: 168610-72-8
(3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 6 steps

2: 80 percent / KH / dimethylformamide / 2 h / Ambient temperature

3: 92 percent / 0.5 N HCl / tetrahydrofuran / 7.25 h / Ambient temperature

4: 50.7 mg / KH / tetrahydrofuran / 1 h / -78 °C

5: 22.4 mg / CSA / CH₂Cl₂ / 34 h / Ambient temperature

6: 93 percent / TBAF / tetrahydrofuran / 5.5 h / Ambient temperature

With hydrogenchloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00373-6

Reference yield:

: 195436-27-2
4-Benzyloxy-5-(1-ethoxy-ethoxymethyl)-benzo[1,3]dioxole

: 168610-72-8
(3aR,4S,7R,7aS)-7-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethoxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / 0.5 N HCl / tetrahydrofuran / 7.25 h / Ambient temperature

2: 50.7 mg / KH / tetrahydrofuran / 1 h / -78 °C

3: 22.4 mg / CSA / CH₂Cl₂ / 34 h / Ambient temperature

4: 93 percent / TBAF / tetrahydrofuran / 5.5 h / Ambient temperature

With hydrogenchloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(97)00373-6