6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

Base Information

Chemical Name:6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one
CAS No.:1360055-67-9
Molecular Formula:C₃₅H₃₈FN₇O₃
Molecular Weight:623.73
Hs Code.:

6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

Synonyms:6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

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Chemical Property of 6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

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Technology Process of 6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

There total 9 articles about 6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360057-17-5
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(1-methyl-5-(5-(1-methylpiperidin-4-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)benzyl acetate

: 1360055-67-9
6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 - 40 ℃;

Reference yield:

: 1231930-22-5
tert-butyl 6-nitropyridine-3′,6′-dihydro-[3,4′-pyridine]-1′(2′H)-carboxylate

: 1360055-67-9
6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 22 h

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 18 h / Inert atmosphere

4: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

5: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / Inert atmosphere

6: sodium hydroxide / tetrahydrofuran / 20 - 40 °C

With potassium phosphate; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; butan-1-ol;

Reference yield:

: 1198408-35-3
6-amino-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester

: 1360055-67-9
6-tert-Butyl-8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 18 h / Inert atmosphere

3: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

4: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / Inert atmosphere

5: sodium hydroxide / tetrahydrofuran / 20 - 40 °C

With potassium phosphate; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; butan-1-ol;