[(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid

Base Information

Chemical Name:[(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid
CAS No.:165063-81-0
Molecular Formula:C₂₃H₂₃Cl₂N₃O₉
Molecular Weight:556.356
Hs Code.:

Synonyms:[(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid

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Chemical Property of [(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid

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Technology Process of [(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid

There total 4 articles about [(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (4-Acetylamino-phenyl)-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

: 165063-81-0
[(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid

Guidance literature:: With hydrogenchloride; In acetone; for 0.333333h; Ambient temperature;
DOI:10.1021/ja00128a006

Reference yield:

: 18699-02-0
4-acetamidophenylacetic acid

: 165063-81-0
[(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 23 h / Ambient temperature

2: 79 percent / 10percent aq. HCl / acetone / 0.33 h / Ambient temperature

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone;
DOI:10.1021/ja00128a006

Reference yield:

: 56-75-7,85666-84-8
chloramphenicol

: 165063-81-0
[(2R,3R)-3-[2-(4-Acetylamino-phenyl)-acetoxy]-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propoxy]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 80 min

2: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 23 h / Ambient temperature

3: 79 percent / 10percent aq. HCl / acetone / 0.33 h / Ambient temperature

With hydrogenchloride; dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone;
DOI:10.1021/ja00128a006