18699-02-0Relevant articles and documents
HYALURONIC ACID DERIVATIVE AND DRUG CONTAINING THE SAME
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Paragraph 0148, (2018/09/08)
The present invention relates to a hyaluronic acid derivative in which an anti-inflammatory drug is bound via a covalent bond, wherein the structure of the hyaluronic acid derivative is represented by following formula (4) or (5): ???????? HA-SP-NSAID?????(4) ???????? HA-SP-DMARD?????(5) wherein HA represents a hyaluronic acid chain; SP represents a spacer residue; NSAID represents a non-steroidal anti-inflammatory drug residue, DMARD represents a disease-modifying anti-rheumatic drug residue, and - represents the covalent bond, wherein the spacer binds to a carboxyl group of the hyaluronic acid via an amide bond and the anti-inflammatory drug selected from non-steroidal anti-inflammatory drugs and disease-modifying anti-rheumatic drugs binds to the spacer via an ester bond, an amide bond or a thioester bond.
Method for preparing 4-acetylaminophenylacetic acid
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Paragraph 0029-0030, (2017/05/26)
The invention discloses a method for preparing 4-acetylaminophenylacetic acid. The method includes the steps that p-nitrophenylacetic acid, N,N-dimethylacetamide and ammonium chloride are evenly mixed, heating reflux, cooling and crystallizing are conducted, and crystals are obtained to obtain 4-acetylaminophenylacetic acid. The production cost is low, the yield is high, product purity is good, operation is easy, the production period is short, and the method is suitable for industrial mass production.
ROR-GAMMA MODULATORS AND USES THEREOF
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Page/Page column 40, (2016/01/21)
The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparation. The invention further relates to pharmaceutical compositions containing the compounds and their use in the treatment of diseases or disorders mediated by RORγ.