2-Acetyl-3-bromo-benzothiophene

Base Information

• Chemical Name: 2-Acetyl-3-bromo-benzothiophene
• CAS No.: 99661-07-1
• Molecular Formula: C10H7 Br O S
• Molecular Weight: 255.135
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40443811
• Nikkaji Number: J1.290.155K
• Wikidata: Q82261767
• Mol file: 99661-07-1.mol

Synonyms:2-Acetyl-3-bromo-benzothiophene;99661-07-1;2-Acetyl-3-bromo-benzo[b]thiophene;2-Acetyl-3-bromobenzo[b]thiophene;1-(3-BROMO-1-BENZOTHIOPHEN-2-YL)ETHANONE;1-(3-bromobenzo[b]thiophen-2-yl)ethanone;Ethanone,1-(3-bromobenzo[b]thien-2-yl)-;SCHEMBL2503631;DTXSID40443811;QVWNKOMTEBSMMC-UHFFFAOYSA-N

Chemical Property of 2-Acetyl-3-bromo-benzothiophene

Chemical Property:

• PSA: 45.31000
• LogP: 3.86640
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 253.94010
• Heavy Atom Count: 13
• Complexity: 219

Purity/Quality:

99.0%Min ^*data from raw suppliers

2-ACETYL-3-BROMO-BENZO[B]THIOPHENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C2=CC=CC=C2S1)Br

Technology Process of 2-Acetyl-3-bromo-benzothiophene

There total 2 articles about 2-Acetyl-3-bromo-benzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-Bromothianaphthene (7342-82-7) + acetyl chloride (75-36-5) → acetyl-2 bromo-3 benzothiophene (99661-07-1)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 20 - 30 ℃; for 5h;

Reference yield: 78.0%

3-Bromothianaphthene (7342-82-7) + acetic anhydride (108-24-7) → acetyl-2 bromo-3 benzothiophene (99661-07-1)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 - 27 ℃; for 6h;

DOI:10.1248/cpb.48.1558

Reference yield:

acetyl-2 bromo-3 benzothiophene (99661-07-1) + phenylboronic acid (98-80-6) → 1-(3-phenylbenzo[b]thiophen-2-yl)ethan-1-one (272459-78-6)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; Heating;

DOI:10.1002/1099-0690(200004)2000:7<1353::AID-EJOC1353>3.0.CO;2-A

upstream raw materials:

3-Bromothianaphthene

acetyl chloride

acetic anhydride

Downstream raw materials:

1-(3-phenylbenzo[b]thiophen-2-yl)ethan-1-one

1-(3-phenyl-benzo[b]thiophen-2-yl)-ethanone oxime

2-(1-(3-phenylbenzo[b]thiophen-2-yl)ethyl)isoindoline-1,3-dione

1-(3-phenylbenzo[b]thiophen-2-yl)ethanamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 99661-07-1 2-ACETYL-3-BROMO-BENZO[B]THIOPHENE

Send

Send

Metric Ton KG G Pound L ML

Send

Send