1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

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Chemical Name:1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene
CAS No.:849833-21-2
Molecular Formula:C₃₈H₅₂O₆Si₂
Molecular Weight:660.998
Hs Code.:

Synonyms:1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

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Chemical Property of 1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

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Technology Process of 1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

There total 3 articles about 1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849833-20-1
6-benzyloxymethyl-2,2-di-tert-butyl-8-(tert-butyl-diphenyl-silanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-sila-naphthalene

: 849833-21-2
1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

Guidance literature:: With 3,3-dimethyldioxirane; In dichloromethane; acetone; at -78 - 0 ℃;
DOI:10.1021/ol0501469

Reference yield:

: 849833-19-8
[2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

: 849833-21-2
1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

2: dimethyldioxirane / CH₂Cl₂; acetone / -78 - 0 °C

With 3,3-dimethyldioxirane; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ol0501469

Reference yield:

: 511256-75-0
(4aR,8R,8aR)-2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalene

: 849833-21-2
1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / 0 °C

1.2: 41 percent / tetrahydrofuran; pentane; diethyl ether / 0.5 h / 0 °C

2.1: 79 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

3.1: dimethyldioxirane / CH₂Cl₂; acetone / -78 - 0 °C

With tert.-butyl lithium; 3,3-dimethyldioxirane; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; acetone; pentane;
DOI:10.1021/ol0501469