[2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

Base Information

Chemical Name:[2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol
CAS No.:849833-19-8
Molecular Formula:C₃₁H₄₆O₅Si₂
Molecular Weight:554.874
Hs Code.:

Synonyms:[2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

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Chemical Property of [2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

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Technology Process of [2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

There total 1 articles about [2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 511256-75-0
(4aR,8R,8aR)-2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalene

: 849833-19-8
[2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

Guidance literature:: (4aR,8R,8aR)-2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at 0 ℃; for 0.5h;

formaldehyd; In tetrahydrofuran; diethyl ether; pentane; at 0 ℃; for 0.5h;
DOI:10.1021/ol0501469

Reference yield: 79.0%

: 849833-19-8
[2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

: 100-39-0
benzyl bromide

: 849833-20-1
6-benzyloxymethyl-2,2-di-tert-butyl-8-(tert-butyl-diphenyl-silanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-sila-naphthalene

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol0501469

Reference yield:

: 849833-19-8
[2,2-di(tert-butyl)-8-(tert-butyldiphenylsilanyloxy)-4,4a,8,8a-tetrahydro-1,3,5-trioxa-2-silanaphthalen-6-yl]methanol

: 849833-21-2
1a-benzyloxymethyl-5,5-di(tert-butyl)-7-(tert-butyldiphenylsilanyloxy)hexahydro-1,2,4,6-tetraoxa-5-silacyclopropa[b]naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

2: dimethyldioxirane / CH₂Cl₂; acetone / -78 - 0 °C

With 3,3-dimethyldioxirane; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ol0501469