tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate
CAS No.:1357182-37-6
Molecular Formula:C₄₈H₅₃N₃O₈S
Molecular Weight:832.03
Hs Code.:

tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

Synonyms:tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

There total 13 articles about tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1357182-37-6
tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In chloroform; at 20 ℃; Inert atmosphere;

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1331747-82-0
benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

: 1357182-37-6
tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/cmdc.201100194

Reference yield:

: 771-99-3
4-phenylpiperidine

: 1357182-37-6
tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine / ethyl acetate / 2 h / 20 °C

4.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

7.1: dmap / dichloromethane / 1 h / 20 °C / Inert atmosphere

With dmap; aluminum (III) chloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; 2.1: Friedel Crafts acylation / 3.1: Rosenmund reduction;
DOI:10.1002/cmdc.201100194