t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate

Base Information

Chemical Name:t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate
CAS No.:1242846-52-1
Molecular Formula:C₂₀H₂₃BrFNO₅S
Molecular Weight:488.375
Hs Code.:

Synonyms:t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate

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Chemical Property of t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate

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Technology Process of t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate

There total 4 articles about t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.8%

: 1242846-51-0
t-butyl 2-(2-bromo-4-((methylamino)methyl)phenoxy)acetate

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1242846-52-1
t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1242846-52-1
t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: methanol / 4 h / 20 °C

2.2: 2 h / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

With 2,6-dimethylpyridine; caesium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 850349-12-1
(2-bromo-4-formyl-phenoxy)-acetic acid tert-butyl ester

: 1242846-52-1
t-butyl 2-(2-bromo-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 4 h / 20 °C

1.2: 2 h / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

With 2,6-dimethylpyridine; In methanol; dichloromethane;