(R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol

Base Information

Chemical Name:(R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol
CAS No.:1224162-04-2
Molecular Formula:C₁₇H₂₀F₃N₃O₄S
Molecular Weight:419.425
Hs Code.:

Synonyms:(R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol

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Chemical Property of (R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol

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Technology Process of (R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol

There total 4 articles about (R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1223498-60-9
2-chloro-4-[(R)-1,2-dimethyl-2-(tetrahydropyran-2-yloxy)propoxy]-5-trifluoromethylpyrimidine

: 5470-49-5
4-methanesulfonylphenylamine

: 1224162-04-2
(R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol

Guidance literature:: 2-chloro-4-[(R)-1,2-dimethyl-2-(tetrahydropyran-2-yloxy)propoxy]-5-trifluoromethylpyrimidine; 4-methanesulfonylphenylamine; In ethanol; at 70 ℃; for 2.5h;

With pyridinium p-toluenesulfonate; In ethanol; at 45 ℃; for 4h;

With sodium hydrogencarbonate; In ethanol;

Reference yield:

: 1223498-54-1
(R)-3-(2-chloro-5-iodo-pyrimidin-4-yloxy)-2-methyl-butan-2-ol

: 1224162-04-2
(R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 22 h / 20 °C

2.1: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 2 h / 90 °C

3.1: ethanol / 2.5 h / 70 °C

3.2: 4 h / 45 °C

With potassium fluoride; copper(l) iodide; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;

Reference yield:

: 53399-77-2
(2R)-3-methyl-2,3-butanediol

: 1224162-04-2
(R)-3-[2-(4-Methanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]-2-methylbutan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / diethyl ether; mineral oil / 0.22 h / 0 - 20 °C

1.2: 0 - 40 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / 22 h / 20 °C

3.1: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 2 h / 90 °C

4.1: ethanol / 2.5 h / 70 °C

4.2: 4 h / 45 °C

With potassium fluoride; copper(l) iodide; pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; ethanol; dichloromethane; mineral oil;