2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide

Base Information

Chemical Name:2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide
CAS No.:1262786-32-2
Molecular Formula:C₂₇H₃₃F₃N₄O₂S
Molecular Weight:534.646
Hs Code.:

Synonyms:2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide

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Chemical Property of 2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide

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Technology Process of 2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide

There total 6 articles about 2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1648-99-3
2,2,2-Trifluoroethanesulfonyl chloride

: 1262786-55-9
4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenyl-1-butanamine

: 1262786-32-2
2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 29940-88-3
4-oxo-2-phenyl-butyronitrile

: 1262786-32-2
2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: hydrogen; ammonia / Raney Nickel / ethanol; water / 18 h / 2585.81 Torr / Fischer-Porter apparatus

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; Raney Nickel; In ethanol; dichloromethane; water;

Reference yield:

: 5292-53-5
diethyl benzalmalonate

: 1262786-32-2
2,2,2-trifluoro-N-{4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}ethanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / ethanol / 18 h / 70 °C

2.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C / Inert atmosphere

5.1: hydrogen; ammonia / Raney Nickel / ethanol; water / 18 h / 2585.81 Torr / Fischer-Porter apparatus

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With lithium borohydride; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; Raney Nickel; In tetrahydrofuran; ethanol; dichloromethane; water;