5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

Base Information

Chemical Name:5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine
CAS No.:1449737-58-9
Molecular Formula:C₁₆H₁₀BrF₃N₄O₂
Molecular Weight:427.18
Hs Code.:

Synonyms:5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

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Chemical Property of 5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

Chemical Property:

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Technology Process of 5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

There total 8 articles about 5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449737-59-0
5-bromo-4-chloro-7-methyl-8-nitroquinazoline

: 98-16-8
3-trifluoromethylaniline

: 1449737-58-9
5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 26 ℃; for 12h;

Reference yield:

: 65078-05-9
4-methyl-2-nitrobenzamide

: 1449737-58-9
5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: iron; ammonium chloride / ethanol; water / 2 h / Reflux

2: 4 h / 110 °C / Sealed tube

3: bromine; acetic acid / methanol / 4 h / 22 - 26 °C

4: sulfuric acid; nitric acid / 12 h / 0 - 26 °C

5: trichlorophosphate / 4 h / Reflux

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 - 26 °C

With sulfuric acid; bromine; nitric acid; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 39549-79-6
2-amino-4-methylbenzamide

: 1449737-58-9
5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 4 h / 110 °C / Sealed tube

2: bromine; acetic acid / methanol / 4 h / 22 - 26 °C

3: sulfuric acid; nitric acid / 12 h / 0 - 26 °C

4: trichlorophosphate / 4 h / Reflux

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 - 26 °C

With sulfuric acid; bromine; nitric acid; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol;