39549-79-6

Basic information

• Product Name: 2-Amino-4-methylbenzamide
• Synonyms: 2-AMINO-4-METHYLBENZAMIDE;Benzamide, 2-amino-4-methyl- (9CI);2-Amino-4-methylbenzamide ,98%
• CAS NO: 39549-79-6
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: AMIDE;Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 39549-79-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 147 °C
• Boiling Point: 282.783 °C at 760 mmHg
• Flash Point: 124.823 °C
• Appearance: /
• Density: 1.185 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.98±0.50(Predicted)
• CAS DataBase Reference: 2-Amino-4-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-methylbenzamide(39549-79-6)
• EPA Substance Registry System: 2-Amino-4-methylbenzamide(39549-79-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-36-22
• Safety Statements: 26-36/37/39-36/37-36
• Hazardous Substances Data: 39549-79-6(Hazardous Substances Data)

Usage

General Description

2-Amino-4-methylbenzamide is a chemical compound with the molecular formula C8H10N2O. It is a derivative of benzamide, containing an amino group and a methyl group attached to the benzene ring. 2-Amino-4-methylbenzamide is used in organic synthesis and pharmaceutical research, as well as in industrial processes. It is a white crystalline solid with a melting point of 166-168°C, and it is soluble in organic solvents such as methanol, ethanol, and acetone. 2-Amino-4-methylbenzamide has been studied for its potential biological activities, including as an inhibitor of protein tyrosine phosphatase 1B, which could have implications for the treatment of diabetes and obesity.

InChI:InChI=1/C8H10N2O/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,9H2,1H3,(H2,10,11)

Upstream product

• 26830-95-5 4-methyl-2-nitrobenzonitrile 
• 26830-96-6 5-methyl-2-cyanoaniline 
• 7647-01-0 hydrogenchloride 
• 65078-05-9 4-methyl-2-nitrobenzamide 
• 27329-27-7 4-methyl-2-nitrobenzoic acid 
• 24920-35-2 4-methyl-2-nitrobenzenediazonium 
• 131002-03-4 4-methyl-2- bromobenzamide 
• 63480-11-5 7-methyl-2H-3,1-benzoxazine-2,4(1H)-dione 
• 2305-36-4 4-methylanthranilic acid 
• 50424-81-2 4-methyl-2-nitro-benzoyl chloride 
• 1397833-54-3 (2-amino-4-methylphenyl) (benzotriazole-1-yl)methanone 

Downstream Products

• 2305-36-4 4-methylanthranilic acid 
• 1241915-26-3 2-((4-fluorophenyl)(hydroxy)methyl)-7-methylquinazolin-4-ol 
• 1241915-31-0 2-(2,2-difluoro-2-(4-fluorophenyl)acetamido)-4-methylbenzamide 
• 1449737-58-9 5-bromo-7-methyl-8-nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine 
• 943606-89-1 7-methyl-N⁴-(3-(trifluoromethyl)phenyl)quinazoline-4,8-diamine 
• 75844-40-5 7-methyl-quinazolin-4(3H)-one 
• 1269219-55-7 7-methyl-2-(4-methoxyphenyl)quinazolin-4(3H)-one 
• 1093101-65-5 8-amino-7-methylquinazolin-4(3H)-one 
• 1093101-48-4 4-(8-amino-7-methylquinazolin-4-ylamino)benzonitrile 
• 1093101-47-3 4-(6-bromo-7-methyl-8-nitroquinazolin-4-ylamino)benzonitrile 
• 1093100-62-9 N₈-(3-(9H-purin-6-yI)pyridin-2-yI)-N₄-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine 
• 1093100-51-6 4-(8-(3-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)pyridin-2-ylamino)-7-methylquinazolin-4-ylamino)benzonitrile 
• 1093100-19-6 4-(8-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2-ylamino)-7-methylquinazolin-4-ylamino)benzonitrile 
• 1093100-21-0 4-(8-(3-(9H-purin-6-yI)pyridin-2-ylamino)-7-methylquinazolin-4-ylamino)benzonitrile 

Relevant articles and documents

COMBINATION THERAPY FOR TREATING MPS1

The application is directed to compounds of formula (I) and their salts and solvates, wherein B, R1, R2, R3, R3', R4, R4', and R5 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., MPS1, optionally in combination with α-L-iduronidase or an analog or variant thereof, e.g., laronidase.

Substrate Profiling of the Cobalt Nitrile Hydratase from Rhodococcus rhodochrous ATCC BAA 870

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a biaryl axis, prepared by the Suzuki coupling reaction, Morita–Baylis–Hillman adducts, heteroatomlinked diarylpyridines prepared by Buchwald–Hartwig crosscoupling reactions and imidazo[1,2a]pyridines prepared by the Groebke–Blackburn–Bienaymé multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the biaryl compounds and Morita–Baylis–Hillman products but not the Groebke–Blackburn–Bienaymé products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound.

Trash to treasure: Eco-friendly and practical synthesis of amides by nitriles hydrolysis in WepPA

The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group tolerance, prominent chemoselectivity, and good reusability. Notably, a magnification experiment in this bio-based solvent at 100 mmol further demonstrated its practicability.