tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine

Base Information

Chemical Name:tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine
CAS No.:372159-50-7
Molecular Formula:C₂₀H₃₁NO₆
Molecular Weight:381.469
Hs Code.:

Synonyms:tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine

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Technology Process of tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine

There total 4 articles about tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 372159-49-4
tert-butyl (4S)-4-{[(1H-imidazol-1-ylthiocarbonyl)oxy](2-methoxy-6-methoxymethoxy)phenylmethyl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 372159-50-7
tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 18h; Heating;
DOI:10.1016/S0957-4166(01)00202-6

Reference yield:

: 57234-28-3
1-methoxy-3-(methoxymethoxy)benzene

: 372159-50-7
tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / 2 h / Heating

1.2: 70 percent / diethyl ether / 0.25 h / Heating

2.1: 66 percent / tetrahydrofuran / 26 h / Heating

3.1: 60 percent / Bu₃SnH; AIBN / toluene / 18 h / Heating

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1016/S0957-4166(01)00202-6

Reference yield:

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 372159-50-7
tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / 2 h / Heating

1.2: 70 percent / diethyl ether / 0.25 h / Heating

2.1: 66 percent / tetrahydrofuran / 26 h / Heating

3.1: 60 percent / Bu₃SnH; AIBN / toluene / 18 h / Heating

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; diethyl ether; hexane; toluene;
DOI:10.1016/S0957-4166(01)00202-6