2-(4-Fluorophenyl)propane-1,3-diol

Base Information

Chemical Name:2-(4-Fluorophenyl)propane-1,3-diol
CAS No.:204201-52-5
Molecular Formula:C₉H₁₁FO₂
Molecular Weight:170.184
Hs Code.:
European Community (EC) Number:824-449-4

Synonyms:2-(4-Fluorophenyl)propane-1,3-diol;204201-52-5;2-(4-fluorophenyl)-1,3-propanediol;SCHEMBL1772818;PFYTWIIZQFTTOS-UHFFFAOYSA-N;AKOS006292998;EN300-1587849

Suppliers and Price of 2-(4-Fluorophenyl)propane-1,3-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2-(4-Fluorophenyl)propane-1,3-diol

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:170.07430775
Heavy Atom Count:12
Complexity:118

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(CO)CO)F

Technology Process of 2-(4-Fluorophenyl)propane-1,3-diol

There total 4 articles about 2-(4-Fluorophenyl)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2965-90-4
diethyl 2-(4-fluorophenyl)malonate

: 204201-52-5
2-(4-fluorophenyl)propane-1,3-diol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; Reflux;
DOI:10.1002/ejoc.201301737

Reference yield:

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 204201-52-5
2-(4-fluorophenyl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

1.2: 80 percent / tetrahydrofuran / 14 h / 20 °C

2.1: 65 percent / LiAlH₄ / diethyl ether / 24 h / 20 °C

With lithium aluminium tetrahydride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol701720m

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 204201-52-5
2-(4-fluorophenyl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / 14 h / 20 °C

2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

2.2: 80 percent / tetrahydrofuran / 14 h / 20 °C

3.1: 65 percent / LiAlH₄ / diethyl ether / 24 h / 20 °C

With lithium aluminium tetrahydride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol701720m