2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile

Base Information

Chemical Name:2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile
CAS No.:1378040-21-1
Molecular Formula:C₁₃H₆ClFN₆
Molecular Weight:300.682
Hs Code.:

Synonyms:2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile

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Chemical Property of 2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile

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Technology Process of 2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile

There total 3 articles about 2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378039-78-1
4-azido-5-fluoro-pyridine-3-carbaldehyde

: 53312-77-9
2-amino-3-chlorobenzonitrile

: 1378040-21-1
2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile

Guidance literature:: With titanium tetrachloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 2546-56-7
4-chloro-3-fluoro-pyridine

: 1378040-21-1
2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 18.75 h / -78 - -30 °C

1.2: 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: triethylamine; titanium tetrachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; sodium azide; titanium tetrachloride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1060802-34-7
4-chloro-5-fluoropyridine-3-carboxaldehyde

: 1378040-21-1
2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

2: triethylamine; titanium tetrachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With sodium azide; titanium tetrachloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;