Technology Process of 2-amino-2-(4-(pentanetyloxy)phenethyl)propane-1,3-diol hydrochloride
There total 11 articles about 2-amino-2-(4-(pentanetyloxy)phenethyl)propane-1,3-diol hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-acetamido-2-(4-(pentanetyloxy)phenethyl)propane-1,3-diyl diacetate;
With
lithium hydroxide;
In
methanol; water;
Reflux;
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 3h;
DOI:10.1039/c8cc05643a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; dmap / tetrahydrofuran / 72 h / 20 °C
2.1: palladium on activated carbon; hydrogen / ethanol / 0.75 h / 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Schlenk technique; Inert atmosphere
4.1: lithium hydroxide / water; methanol / Reflux
4.2: 3 h / 20 °C
With
dmap; palladium on activated carbon; hydrogen; caesium carbonate; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c8cc05643a
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: methyl-triphenylphosphonium iodide; sodium hydride / tetrahydrofuran / 20 °C
2.1: borane-THF / 0 - 20 °C
2.2: 0 - 20 °C
3.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Schlenk technique
4.2: 40 h / 95 °C / Schlenk technique
5.1: lithium chloride; sodium tetrahydroborate / tetrahydrofuran / 60 h / 0 - 20 °C
6.1: triethylamine; dmap / tetrahydrofuran / 72 h / 20 °C
7.1: palladium on activated carbon; hydrogen / ethanol / 0.75 h / 20 °C
8.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Schlenk technique; Inert atmosphere
9.1: lithium hydroxide / water; methanol / Reflux
9.2: 3 h / 20 °C
With
1H-imidazole; dmap; sodium tetrahydroborate; borane-THF; palladium on activated carbon; hydrogen; iodine; methyl-triphenylphosphonium iodide; sodium hydride; caesium carbonate; triethylamine; triphenylphosphine; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c8cc05643a
