(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

Base Information

Chemical Name:(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester
CAS No.:1373492-32-0
Molecular Formula:C₁₄H₁₄ClNO₃
Molecular Weight:279.723
Hs Code.:

Synonyms:(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

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Chemical Property of (2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

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Technology Process of (2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

There total 5 articles about (2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.7%

: 1373492-31-9
1,6-dihydro-2H-pyridin-3-one trifluoroacetate

: 85259-19-4,622835-93-2,66504-71-0
methyl 2-bromo-2-(2-chlorophenyl)acetate

: 1373492-32-0
(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 120568-74-3
N-allyl-N-(2-hydroxy-3-butenyl)amine

: 1373492-32-0
(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / 1,4-dioxane; water / 20 °C / Cooling in water bath

2: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere

3: pyridinium chlorochromate / dichloromethane / 1 h / Inert atmosphere

4: dichloromethane / 4 h / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With potassium carbonate; pyridinium chlorochromate; sodium hydroxide; Grubbs catalyst first generation; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: allyl-(1-hydroxyallyl)carbamic acid tert-butyl ester

: 1373492-32-0
(2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 1 h / Inert atmosphere

3: dichloromethane / 4 h / 20 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With potassium carbonate; pyridinium chlorochromate; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;