N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

Base Information

Chemical Name:N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide
CAS No.:1112979-29-9
Molecular Formula:C₂₀H₁₆N₄O₂S₂
Molecular Weight:408.505
Hs Code.:

Synonyms:N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

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Chemical Property of N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

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Technology Process of N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

There total 4 articles about N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 696-63-9
4-Methoxybenzenethiol

: 1112980-26-3
N-(6-(2-chloropyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

: 1112979-29-9
N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

Guidance literature:: 4-Methoxybenzenethiol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1.08333h;

N-(6-(2-chloropyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 15864-32-1
2-amino-6-bromobenzothiazole

: 1112979-29-9
N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 0 - 20 °C / Cooling with ice; Inert atmosphere

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 2.33 h / Inert atmosphere; Heating

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 95 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; sodium carbonate; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki coupling;
DOI:10.1021/jm1014605

Reference yield:

: 885069-14-7
N-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzothiazol-2-yl]acetamide

: 1112979-29-9
N-(6-(2-(4-methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 95 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 1.1: Suzuki coupling;
DOI:10.1021/jm1014605