885069-14-7Relevant articles and documents
HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF
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, (2018/02/20)
The present disclosure provides heteroaryl compounds of formulas (I), (Ia) and (Ib), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosi
Medicine with necrocytosis inhibitory activity and application thereof
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, (2018/03/24)
The invention provides a medicine with the necrocytosis inhibitory activity. The medicine with the necrocytosis inhibitory activity contains one or two of the following compounds. The invention further provides application of the medicine with the necrocy
MECHANISTIC TARGET OF RAPAMYCIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF
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, (2018/04/11)
Selective mTOR inhibitors of formulas (I)-(III), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from abnormal cell growth, functions, or behaviors mediated by an mTOR kinase and/or one or more PI3K enzyme, are provided. Such diseases and disorder include cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
Enhanced treatment regimens using mTor inhibitors
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, (2015/11/27)
The present invention provides for methods and pharmaceutical compositions comprising inhibitors of mTorC1 and/or mTorC2. In some aspects, the invention provides for treatment regimens resulting in enhanced treatment efficacy and better tolerability.
Benzothiazole Kinase Inhibitors and Methods of Use
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, (2015/09/22)
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating lipid kinases such PI3 kinases, tryosine kinases and protein kinases such as mTOR. Also provided in the present invention are methods of using these compositions to modulate these kinases especially for therapeutic applications.
Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase γ
Collier, Philip N.,Martinez-Botella, Gabriel,Cornebise, Mark,Cottrell, Kevin M.,Doran, John D.,Griffith, James P.,Mahajan, Sudipta,Maltais, Fran?ois,Moody, Cameron S.,Huck, Emilie Porter,Wang, Tiansheng,Aronov, Alex M.
, p. 517 - 521 (2015/02/19)
Phosphoinositide 3-kinase γ (PI3Kγ) is an attractive target to potentially treat a range of disease states. Herein, we describe the evolution of a reported phenylthiazole pan-PI3K inhibitor into a family of potent and selective benzothiazole inhibitors. U
Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors
Yang, Zhaohui,Ma, Haikuo,Sun, Zhijian,Luo, Lusong,Tian, Sheng,Zheng, Jiyue,Zhang, Xiaohu
, p. 3665 - 3670 (2015/08/06)
Abstract Vismodegib is the first FDA approved cancer therapy based on inhibition of aberrant hedgehog signaling. Like most cancer therapies, vismodegib suffered from resistance, even during clinical development. Numerous reports demonstrated that simultan
COMBINATION PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Paragraph 0499, (2014/12/09)
The present invention provides for methods and pharmaceutical compositions for treating proliferative disorders. In one aspect, the method comprises administration of two cell-cycle suppressors having a synergistic effect. In another aspect, two cell-cycle suppressors having a synergistic effect are provided in a pharmaceutical composition.
COMBINATION OF KINASE INHIBITORS AND USES THEREOF
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, (2014/10/04)
The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject.
UREA DERIVATIVE HAVING PI3K INHIBITORY ACTIVITY
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, (2012/03/26)
Provided is a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a urea derivative shown in the present specification, or a pharmaceutically acceptable salt thereof.