2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester

Base Information

• Chemical Name: 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester
• CAS No.: 327621-02-3
• Molecular Formula: C₂₂H₂₅NO₆
• Molecular Weight: 399.444

Synonyms:2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester

Chemical Property of 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester

Chemical Property:

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Technology Process of 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester

There total 4 articles about 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid (327621-01-2) + methyl iodide (74-88-4) → 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester (327621-02-3)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/jo9018792

Reference yield: 65.0%

tris(2-formylphenyl)bismuthine + (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester (4326-36-7) → 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester (327621-02-3)

Guidance literature:

With pyridine; oxygen; copper diacetate; In dichloromethane; at 50 ℃; for 16h; Sealed tube;

DOI:10.1002/ejoc.202000790

Reference yield:

2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid (327621-01-2) + methyl iodide (74-88-4) → 2-(S)-tert-butoxycarbonylamino-3-[4-(2-dimethoxymethylphenoxy)phenyl]propionic acid methyl ester (1192849-57-2) + 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester (327621-02-3)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1021/jo9018792

upstream raw materials:

2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid

methyl iodide

Boc-Tyr-OH

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

Downstream raw materials:

2-(R)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-iodopropionic acid methyl ester

2-(S)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-hydroxypropionic acid methyl ester

2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionic acid

2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionic acid methyl ester

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