327621-01-2Relevant academic research and scientific papers
Pd-catalysed C-C macrocyclisation of a simple tripeptide: Efficient total synthesis of K-13
Perez-Gonzalez,Jackson
, p. 2423 - 2424 (2000)
The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C
Application of Negishi cross-coupling to the synthesis of the cyclic tripeptides OF4949-III and K-13
Nolasco, Luca,Gonzalez, Manuel Perez,Caggiano, Lorenzo,Jackson, Richard F. W.
experimental part, p. 8280 - 8289 (2010/02/17)
(Chemical Equation Presented) Syntheses of the cyclic tripeptides OF4949-III 1 and K-13 2 are reported, in which the key steps are intermolecular and intramolecular Negishi cross-coupling reactions, respectively. In addition, the synthesis of a protected
Novel derivatives of amino acids for treatment of obesity and related disorders
-
Page/Page column 33-34, (2010/11/25)
Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorder
