1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol

Base Information

• Chemical Name: 1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol
• CAS No.: 137117-97-6
• Molecular Formula: C₂₁H₂₇F₂N₃O
• Molecular Weight: 375.462

Synonyms:1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol

Chemical Property of 1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol

Chemical Property:

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Technology Process of 1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol

There total 3 articles about 1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

→ 1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol (137117-97-6)

Guidance literature:

Reference yield:

1-(4-fluorophenyl)methyl-piperazine (27469-60-9) → 1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol (137117-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 69.6 percent / K₂CO₃ / acetonitrile / 96 h / Ambient temperature

2: ethanol / 28 h / 110 °C

With potassium carbonate; In ethanol; acetonitrile;

DOI:10.1021/jm00102a001

Reference yield:

1-<1-(2,3-epoxypropyl)>-4-piperazine (125345-89-3) + methylamine (74-89-5) → 1-Methylamino-3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-2-propanol (137117-97-6)

Guidance literature:

In ethanol; at 110 ℃; for 28h;

DOI:10.1021/jm00102a001

upstream raw materials:

1-<1-(2,3-epoxypropyl)>-4-piperazine

methylamine

1-(4-fluorophenyl)methyl-piperazine

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