(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1352743-40-8
Molecular Formula:C₂₉H₃₄F₃NO₄Si
Molecular Weight:545.674
Hs Code.:

Synonyms:(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Chemical Property of (R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 10 articles about (R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1352743-15-7
(R)-2-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-6-methylpyridin-4(1H)-one

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 1352743-40-8
(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-15-7
(R)-2-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-6-methylpyridin-4(1H)-one

: 64312-89-6
Mosher's acid chloride

: 1352743-40-8
(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

: (S)-2-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

: 1352743-40-8
(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]-6-methylpyridin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 16 h / Reflux

2: pyridine / dichloromethane / 6 h / 20 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.201100681