(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

Base Information

Chemical Name:(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide
CAS No.:1352743-07-7
Molecular Formula:C₁₉H₂₉NO₃Si
Molecular Weight:347.53
Hs Code.:

Synonyms:(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

Chemical Property:

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Technology Process of (R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

There total 3 articles about (R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-66-7
4-Aminopent-3-en-2-one

: 140840-39-7
2-(tert-butyldimethylsilyloxy)phenylacetyl chloride

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejoc.201100681

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / tetrahydrofuran / 16 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201100681

Reference yield:

: 140840-38-6
C₂₀H₃₆O₃Si₂

: 1352743-07-7
(R,Z)-2-(tert-butyldimethylsiloxy)-N-(4-oxopent-2-en-2-yl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1002/ejoc.201100681