C₁₈H₁₈ClNO₃

Base Information

Chemical Name:C₁₈H₁₈ClNO₃
CAS No.:1311412-61-9
Molecular Formula:C₁₈H₁₈ClNO₃
Molecular Weight:331.799
Hs Code.:

C<sub>18</sub>H<sub>18</sub>ClNO<sub>3</sub>

Synonyms:C₁₈H₁₈ClNO₃

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Chemical Property of C₁₈H₁₈ClNO₃

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Technology Process of C₁₈H₁₈ClNO₃

There total 11 articles about C₁₈H₁₈ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 21640-48-2
3-chlorohydrocinnamic acid

: 138603-50-6
cis-4-amino-3-chromanol

: 1311412-61-9
C₁₈H₁₈ClNO₃

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at -10 - 0 ℃; for 2h;

Reference yield:

: 49701-11-3
8-chloro-2,3-dihydro-4H-1-benzopyran-4-one

: 1311412-61-9
C₁₈H₁₈ClNO₃

Guidance literature:: Multi-step reaction with 7 steps

1: bromine / dichloromethane / 0.5 h / Reflux

2: sodium tetrahydroborate; methanol / 0.5 h / 0 - 20 °C

3: sulfuric acid / 45 - 50 °C

4: water / acetonitrile / 48 h / Reflux

5: Chiralpak Daicel^.(R). AD / acetonitrile / Resolution of racemate

6: hydrogen / palladium on carbon / 760.05 Torr

7: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / -10 - 0 °C

With methanol; sodium tetrahydroborate; sulfuric acid; water; hydrogen; bromine; triethylamine; HATU; palladium on carbon; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 95-57-8
2-monochlorophenol

: 1311412-61-9
C₁₈H₁₈ClNO₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / water / 4.5 h / Reflux

1.2: 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C / Cooling with ice

3.1: aluminum (III) chloride / dichloromethane / 20 °C

4.1: bromine / dichloromethane / 0.5 h / Reflux

5.1: sodium tetrahydroborate; methanol / 0.5 h / 0 - 20 °C

6.1: sulfuric acid / 45 - 50 °C

7.1: water / acetonitrile / 48 h / Reflux

8.1: Chiralpak Daicel^.(R). AD / acetonitrile / Resolution of racemate

9.1: hydrogen / palladium on carbon / 760.05 Torr

10.1: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / -10 - 0 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; oxalyl dichloride; sulfuric acid; water; hydrogen; bromine; triethylamine; HATU; sodium hydroxide; palladium on carbon; N,N-dimethyl-formamide; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;