1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate

Base Information

Chemical Name:1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate
CAS No.:1620488-74-5
Molecular Formula:C₂₇H₂₆FN₅O₄
Molecular Weight:503.533
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate

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Chemical Property of 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate

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Technology Process of 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate

There total 5 articles about 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 262375-98-4
[4-(4-amino-phenyl)-piperazin-1-yl]-furan-2-yl-methanone

: 1620488-80-3
C₁₂H₁₀ClFN₂O₂

: 1620488-74-5
1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2014.07.001

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1620488-74-5
1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 2 h / Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2585.81 Torr

3: triethylamine / acetonitrile / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2014.07.001

Reference yield:

: 262375-97-3
furan-2-yl-[4-(4-nitro-phenyl)-piperazin-1-yl]-methanone

: 1620488-74-5
1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 2585.81 Torr

2: triethylamine / acetonitrile / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2014.07.001