262375-98-4

Basic information

• Product Name: 4-[4-(2-FUROYL)PIPERAZIN-1-YL]ANILINE
• Synonyms: AKOS BB-7965;4-[4-(2-FUROYL)PIPERAZIN-1-YL]ANILINE;ASISCHEM A27489;(4-(4-Aminophenyl)piperazin-1-yl)(furan-2-yl)methanone
• CAS NO: 262375-98-4
• Molecular Formula: C₁₅H₁₇N₃O₂
• Molecular Weight: 271.31
• Mol File: 262375-98-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[4-(2-FUROYL)PIPERAZIN-1-YL]ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(2-FUROYL)PIPERAZIN-1-YL]ANILINE(262375-98-4)
• EPA Substance Registry System: 4-[4-(2-FUROYL)PIPERAZIN-1-YL]ANILINE(262375-98-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 262375-98-4(Hazardous Substances Data)

Upstream product

• 40172-95-0 N-(furan-2-carbonyl)piperazine 
• 350-46-9 4-Fluoronitrobenzene 
• 262375-97-3 furan-2-yl-[4-(4-nitro-phenyl)-piperazin-1-yl]-methanone 

Downstream Products

• 1620488-74-5 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl N-[4-[4-(furan-2-carbonyl)piperazin-1-yl]phenyl]carbamate 

Relevant articles and documents

Design and synthesis of some new 1-phenyl-3/4-[4-(aryl/heteroaryl/alkyl-piperazine1-yl)-phenyl-ureas as potent anticonvulsant and antidepressant agents

A series of 1-phenyl-3/4-[4-(aryl/heteroaryl/alkyl-piperazine1-yl)-phenyl-urea derivatives (29–42) were designed, synthesized and evaluated for their anticonvulsant activity by using maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure tests. The acute neurotoxicity was checked by rotarod assay. Most of the test compounds were found effective in both seizure tests. Compound 30 (1-{4-[4-(4-chloro-phenyl)-piperazin-1-yl]-phenyl}-3-phenyl-urea) exhibited marked anticonvulsant activity in MES as well as scPTZ tests. The phase II anticonvulsant quantification study of compound 30 indicates the ED50value of 28.5?mg/kg against MES induced seizures. In addition, this compound also showed considerable protection against pilocarpine induced status epilepticus in rats. Seizures induced by 3-mercaptopropionic acid model and thiosemicarbazide were significantly attenuated by compound 30, which suggested its broad spectrum of anticonvulsant activity. Interestingly, compound 30 displayed better antidepressant activity than standard drug fluoxetine. Moreover, compound 30 appeared as a non-toxic chemical entity in sub-acute toxicity studies.

Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors

A new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives was synthesized. The antifungal activity was evaluated in vitro against different fungal species. The biological results show that the most active compounds possess an antifungal activity comparable or higher than Fluconazole against Candida albicans, non-albicans Candida species, Cryptococcus neoformans and dermathophytes. Because of their racemic nature, the most active compounds 5f and 6c were tested as pure enantiomers. For 6c the (R)-enantiomer resulted more active than the (S)-one, otherwise for 5f the (S)-enantiomer resulted the most active. To rationalize the experimental data, a ligand-based computational study was carried out; the results of the modelling study show that (S)-5f and (R)-6c perfectly align to the ligand-based model, showing the same relative configuration. Preliminary studies on the human lung adenocarcinoma epithelial cells (A549) have shown that 6c, 5e and 5f possess a low cytotoxicity.