cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide

Base Information

Chemical Name:cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide
CAS No.:1394011-69-8
Molecular Formula:C₂₂H₂₄F₃N₃O₄
Molecular Weight:451.445
Hs Code.:

Synonyms:cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide

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Chemical Property of cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide

Chemical Property:

Purity/Quality:

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Technology Process of cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide

There total 4 articles about cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: c-TUCB

: 74-89-5
methylamine

: 1394011-69-8
cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 948304-23-2
cis-4-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)cyclohexyloxy]benzoic acid ethyl ester

: 1394011-69-8
cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine / dichloromethane; methanol / 24 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

3: water; lithium hydroxide / acetonitrile / 20 °C / Inert atmosphere

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; hydrazine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 948304-37-8
cis-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzoic acid ethyl ester

: 1394011-69-8
cis-N-methyl-4-{4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / acetonitrile / 20 °C / Inert atmosphere

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; acetonitrile;