ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate

Base Information

• Chemical Name: ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate
• CAS No.: 891186-73-5
• Molecular Formula: C₂₁H₂₃N₃O₆
• Molecular Weight: 413.43
• Mol file: 891186-73-5.mol

Synonyms:ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate

Chemical Property of ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate

There total 4 articles about ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

chlorocarbonyl-diazo-acetic acid ethyl ester (57072-87-4) + (2,4-dimethoxy-benzyl)-(4-methoxy-phenyl)-amine (3446-77-3) → ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate (891186-73-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ol060298j

Reference yield:

4-methoxy-aniline (104-94-9) → ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate (891186-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 18 h / 165 °C

2: sodium borohydride / CH₂Cl₂; ethanol / 12 h / 0 °C

3: 90 percent / triethylamine / CH₂Cl₂ / 6 h / 20 °C

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane; toluene;

DOI:10.1021/ol060298j

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → ethyl 2-diazo-3-(N-(2,4-dimethoxybenzyl)-N-(4-methoxyphenyl)amino)-3-oxopropanoate (891186-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 18 h / 165 °C

2: sodium borohydride / CH₂Cl₂; ethanol / 12 h / 0 °C

3: 90 percent / triethylamine / CH₂Cl₂ / 6 h / 20 °C

With sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane; toluene;

DOI:10.1021/ol060298j

upstream raw materials:

chlorocarbonyl-diazo-acetic acid ethyl ester

(2,4-dimethoxy-benzyl)-(4-methoxy-phenyl)-amine

4-methoxy-aniline

2,4-Dimethoxybenzaldehyde

Downstream raw materials:

(S)-1-(2,4-dimethoxybenzyl)-5-methoxy-1'-methylspiro[indoline-3,3'-pyrrolidine]-2,2'-dione

1-(2,4-dimethoxy-benzyl)-5-methoxy-2-oxo-3-(2-oxo-ethyl)-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester

3-allyl-1-(2,4-dimethoxy-benzyl)-5-methoxy-2-oxo-2,3-dihydro-1-H-indole-3-carboxylic acid ethyl ester

1-(2,4-dimethoxybenzyl)-5-methoxy-2-[(triisopropylsilyl)oxy]-1H-indole-3-carboxylic acid ethyl ester