1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Base Information

Chemical Name:1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione
CAS No.:1456534-30-7
Molecular Formula:C₂₇H₂₅N₉O₃
Molecular Weight:523.554
Hs Code.:

1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Synonyms:1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

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Chemical Property of 1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

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Technology Process of 1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

There total 8 articles about 1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676491-47-7
2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

: 1456534-45-4
1,3-dimethyl-5-phenyl-1,2,3,4-tetrahydropyridazino[3,4-d]pyrimidine

: 1456534-30-7
1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: With 2-chloro-1,3-dimethyl imidazolium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 2049-80-1
(2-propenyl)propanedioic acid diethyl ester

: 1456534-30-7
1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium; ethanol / 24 h / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 3 h / 80 °C / Inert atmosphere

2.2: pH 8 - 9

3.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; 1,4-dioxane / 2 h / 20 °C

3.2: 3 h / 20 °C

4.1: tetrahydrofuran; diethyl ether / 24 h / 0 - 20 °C / Inert atmosphere

5.1: sodium acetate / acetonitrile / 24 h / 20 °C

6.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 3 h / 100 °C / Inert atmosphere; Sealed tube

7.1: sodium tetrahydroborate; boric acid / methanol / 2 h / 0 - 20 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine; 2-chloro-1,3-dimethyl imidazolium chloride / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium tetrahydroborate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-chloro-1,3-dimethyl imidazolium chloride; ethanol; sodium acetate; boric acid; sodium; potassium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 16019-31-1
5-allyl-4,6-dichloropyrimidine

: 1456534-30-7
1-(1,3-dimethyl-5-phenyl-3,4-dihydropyrimido[4,5-c]pyridazin-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; 1,4-dioxane / 2 h / 20 °C

1.2: 3 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 24 h / 0 - 20 °C / Inert atmosphere

3.1: sodium acetate / acetonitrile / 24 h / 20 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 3 h / 100 °C / Inert atmosphere; Sealed tube

5.1: sodium tetrahydroborate; boric acid / methanol / 2 h / 0 - 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; 2-chloro-1,3-dimethyl imidazolium chloride / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium tetrahydroborate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-chloro-1,3-dimethyl imidazolium chloride; sodium acetate; boric acid; potassium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile;