(S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid

Base Information

Chemical Name:(S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid
CAS No.:643018-84-2
Molecular Formula:C₂₂H₂₆N₂O₆
Molecular Weight:414.458
Hs Code.:

Synonyms:(S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid

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Chemical Property of (S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid

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Technology Process of (S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid

There total 8 articles about (S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.7%

: 65615-90-9
(S)-methyl 3-(4-aminophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

: 118-91-2
ortho-chlorobenzoic acid

: 643018-84-2
(S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid

Guidance literature:: With copper; potassium carbonate; In N,N-dimethyl-formamide; for 2h; Heating;
DOI:10.1002/hlca.200390275

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 643018-84-2
(S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 9.66 g / NaOH / 2-methyl-propan-2-ol / 20 °C / pH 8 - 9

2: 63.2 percent / Et₂O / 0.5 h / cooling

3: 94.4 percent / H₂ / Pd/C / methanol / 2 h

4: 65.7 percent / K₂CO₃; Cu / dimethylformamide / 2 h / Heating

With sodium hydroxide; diethyl ether; hydrogen; copper; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; tert-butyl alcohol; 4: Ullmann-Jourdan condensation;
DOI:10.1002/hlca.200390275

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 643018-84-2
(S)-2-(4-(2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenylamino)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 63.2 percent / Et₂O / 0.5 h / cooling

2: 94.4 percent / H₂ / Pd/C / methanol / 2 h

3: 65.7 percent / K₂CO₃; Cu / dimethylformamide / 2 h / Heating

With diethyl ether; hydrogen; copper; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 3: Ullmann-Jourdan condensation;
DOI:10.1002/hlca.200390275